We aim to map an entire human brain at sub-cellular resolution revealing the connections of this neuronal network. This feat is made possible by synchrotron x-ray microscopy though image acquisition at 3mm per minute and 0.3um resolution.
MAPPING THE NEURONAL NETWORK OF THE ENTIRE HUMAN BRAIN
“Synchrotron for Neuroscience – an Asia Pacific Strategic Enterprise” (SYNAPSE) is a coalition of synchrotron facilities including Pohang Light Source (Korea), Shanghai Synchrotron Radiation Facility, SPring-8 (Japan), Singapore Synchrotron Light Source, Taiwan Photon Source, and Australia Synchrotron, under the Asia Oceania Forum for Synchrotron Radiation Research (AOFSRR), with support from the local synchrotron, neurobiology and computing communities.
What is our objective?
We plan to comprehensively map the neuron network of an entire human brain at sub-cellular level to reveal the connections. This historical target is made possible by the recent performances of synchrotron x-ray microscopy: 0.3 micrometer resolution at 1 mm3/min image taking speed. However, mapping one human brain would take a very long time and generate a huge amount of data. To overcome problems, SYNAPSE adopts a strategy of simultaneous image acquisition by several synchrotrons and coordinated data management. SYNAPSE will also use other advanced imaging techniques besides synchrotron microscopy: infrared spectromicroscopy, super-resolution visible light 3D microscopy and cryo-electron tomography.
Who are we?
The new partnership is built on long-standing and successful collaborations. Our core teams pioneered the special techniques required for SYNAPSE, notably x-ray phase-contrast tomography at micrometer and nanometer scale. In addition to synchrotron facilities, SYNAPSE involves more than 40 other research institutions in biology, materials science, physics, chemistry and engineering from the regional partners.
JOIN OUR INAUGURATION MEETING ON 15TH JANUARY 2020 IN SINGAPORE
National University of Singapore
National Supercomputing Centre
Singapore Synchrotron Light Source (SSLS)
Yong Loo Lin School of Medicine
Department of Pharmacology